There are many aspects to a metaphysical wakeup - such a wakeup being the sudden realization of being self-trapped by deeply held assumptions concerning the nature of reality, the sloughing-off of such assumptions; and the sudden recognition and adoption of alternative possible assumptions.
For example, The Animistic Wakeup.
That would be the recognition that we are killing ourselves (first spiritually, then physically) by our inbuilt assumption that almost everything in the universe is dead (in the sense of unliving, passive, non-conscious, lacking in any purpose) - discarding this assumption - and adopting instead the assumption that everything is alive and (I various ways and to widely varying degrees) conscious and purposive.
Try it as you sit now and look about you - or as you walk somewhere: the effect is utterly remarkable: the world is changed! It is not necessarily a change that will make you happy (that depends on the situation you are in) but it is a change when suddenly life becomes meaning-full and purpose-full and you are no longer lonely but at the centre of a web of uncountable relationships.
Such a wakeup could happen to you, it could happen en masse.
Many people have the potential for such a wake-up - for example the tens of millions who have been deeply moved and permanently affected by Tolkien, Narnia, Harry Potter and other good fantasy books - these people have this potential latent.
What might make it happen?
Well, part of this metaphysical paradigm shift is the recognition that there are multiple influences that are imperceptible - communications that may affect us at the level of the imagination, but of whose origin we are unaware.
HOWEVER - any such realization must be accepted. And at present when someone has such a realization - it is rejected (nearly always, and en masse).
IF such a thing happened - to a lot of people, enough people - it would be a cataclysm; one way or another. Things would never be the same again.
There would be (metaphorically) a stepping out of the shadows of (self-) deception and an experience of blinding illumination.
If, r once, this happens, the end of things would commence - because if it was accepted, everything would change; but if it was rejected then this would be a full, aware and conscious choice to embrace despair as Good.
Because this would be nothing less than a realization of our own sins against the light. We would suddenly find ourselves poised upon a knife-edge - with the choice of repenting (which is to say acknowledging the nature and reality of) our sins; or else denying our sins and relabeling them a Good.
As I say: things would never be the same again: for better, or for (much) worse.