I am assuming, here, that modernity is indeed a hellhole - although mostly a tepid and padded hellhole. The extent to which moderns strive-continually, desperately, to lose themselves in distraction and intoxication and/or stimulate themselves - up to and including cultivated degradation and deliberate self-mutilation - makes this obvious to me (although I accept that the typically successful, exemplary and admired, modern life may strike other people as just 'fun').
Alienation - Needs to be changed to relationship; but not only nor primarily human relationships; but an experienced relationship with the world. Relationship being in both directions - our attitude to the world, the world's attitude to us.
And this relationship needing to be (or become) one of love. Because everything is alive, and in relationship - love (not gravity nor electromagnetism nor any unified field!) is the primary force of reality.
Nihilism - Needs to be changed to meaning, which depends on purpose - and this purpose must be personal, for ourselves and ourselves uniquely.
In the end, this entails a personal God with whom we have a personal relationship; everything is alive - and personal. God (a person/s) has a role or task or destiny for us individually; and we can choose (and it must be a choice - it is not compelled) to accept this, and participate with and modify it - or not.
Despair - Must, of course, be reversed to hope.
And Hope entails that this mortal earthly life be framed by (at least) an eternal after-life; such that mortal life is significant (the vital aspects must be remembered forever, not merely blown-away by the winds of time) yet mortality be known as not-everything in-and-of-itself.
Thus the experience of mortality is eternally significant because it is (in part) part of a progression achievable in no other way.
Significance comes from un-repeatability and permanence combined.