Tuesday 11 August 2015

High IQ genes versus low IQ genes

The following is a draft from a chapter in a book on genius I am co-writing with Ed Dutton:

High-IQ genes versus low-IQ genes

At a genetic level, intelligence may reduce because of a reduction in high intelligence genes in a population and/or as an accumulation of intelligence-damaging mutations in the population.

Differential fertility would lead to a decline in intelligence by a reduction in the proportion of high IQ genes in the population. This happens from a combination of the relatively less intelligent people having on average the most children, and the most intelligent people having very low fertility. Since the most intelligent people are sub-fertile, with less than two offspring per woman, the genes which have made them the most intelligent will decline in each generation - first declining as a proportion of the gene pool, and then declining in absolute prevalence. 

For instance, when there is a woman with ultra-high intelligence who has zero children (which is the most usual outcome among ultra-intelligent women), then whatever it was about her genes which made her so intelligent is eliminated from the gene pool: this is the loss of ‘high-IQ genes’.

But our suggestion of mutation accumulation involves that the additional mechanism of an accumulation of what could be termed ‘low-IQ genes’. So, as well as there being a decline in intelligence from the reduced proportion of high-IQ’ gene, there is also a reduction in in the proportion of low-IQ genes: an increase in the proportion of ‘low IQ genes’ in the population.

High IQ genes have (presumably) been selected for in the past because they increased intelligence, and thereby (under ancestral - especially medieval - conditions) increased reproductive success.

But low IQ genes are not, in general, a product of natural selection: rather they are spontaneously occurring deleterious mutations, which happen with every generation due to any cause of genetic damage (e.g. electromagnetic radiation, chemical damage), or errors in replication.

These mutations will, if not eliminated, accumulate generation upon generation. Therefore when they have accumulated, the low-IQ genes were not 'selected for'; rather it was a matter of lack of selection, relaxation of natural selection. ‘Low IQ gene’ therefore usually means something like a genetic mutation that – in potentially a wide range of ways, by impairing almost any aspect of brain structure, organization or functioning; actively-damages brain processing speed and efficiency, hence reducing general intelligence.

In technical terms, the selection mechanism for eliminating these spontaneously accumulating low IQ genes is mutation-selection balance. The idea is that mutations spontaneously occur and need selectively to be eliminated. In other words, by some means, those organisms which have damaging mutations must fail to reproduce, so they will not hand-on the mutations to the next generation. The process needs to be perfect, over the long terms, otherwise the accumulation of damaging mutations will eventually prevent reproduction and damage survival to cause extinction (the term for this extinction is mutational meltdown).

The term mutation-selection balance refers to the fact that the occurrence of mutations must be balanced by the elimination of mutations: natural selection (including sexual selection – mate choice) must be powerful enough to sieve-out all the deleterious mutations. If natural selection is not strong enough to do this, then mutations will accumulate, brain function will be damaged, and intelligence will decline.  

Each spontaneous mutation has about a fifty-fifty chance of damaging brain function, because the brain depends on a very high proportion of genes to develop normally and make its structural components, its proteins, enzymes, hormones, neurotransmitters and so on. Thus the brain is a large ‘mutational target’ (as Geoffrey Miller has termed it) – and will usually show up, in a quantitative fashion, the amount of mutational damage a person has. In other world, high intelligence requires ‘good genes’ – where good genes means a genome low in mutations; conversely a high mutational load will cause low intelligence.

Before the Industrial Revolution, individuals with a higher mutational load, which means a higher load of low-IQ genes (and therefore lower intelligence) had lower-than-average reproductive success due to very high (indeed, probably near total) childhood mortality rates. But since the child mortality rates fell from more than half to about one percent in most of Europe, almost all babies that are born have survived to adulthood, and most of them have reproduced. Therefore, we must assume that there have by now been several generations – in England at least eight generations - of mutation accumulation. And we must also assume that this has had a significant effect in reducing intelligence.

This produces what is truly a ‘dysgenic’ effect on intelligence, since it is not evolved, not adaptive, not a new ability – but instead a lowering of intelligence due to a pathological process; a destruction of adaptive human intelligence caused by an accumulation of damage.   

And although intelligence decline is a sensitive measure of mutation accumulation – it is not the only consequence. Many other human adaptations would be destroyed by mutation accumulation – including evolved human personality types. As well as pulling down human intelligence; mutation accumulation would be expected to destroy the Endogenous personality, to impair human creativity – and would be a further nail in the coffin of genius.


Valkea said...

I assume child mortality is a "blunt instrument" in increasing or maintaining intelligence. It kills relatively large proportion of high intelligence people also?

Bruce Charlton said...

@V - Yes a blunt instrument indeed! Comparative biological evidence suggests that this kind of crude, harsh selection was stronger in humans than in other species - perhaps because the complexity of the human brain and its vulnerability to mutations meant that it was even more important that spontaneous mutations should be filtered-out each generation.

Of course, I am *not* approving of high child mortality rates, the near elimination of which has been perhaps the greatest contribution of modernity to genuine human happiness.

But such massive changes in selection will surely have major consequences - as WD Hamilton pointed out from 60 years ago up to his death in 2000, as almost a lone voice.

I personally do not think think these consequences could realistically be avoided - only somewhat delayed and ameliorated; nor (morally) do I think we should even try to avoid them (which would require something like a massive coercive programme of sterilization/ extermination - which would, no doubt, be administered by the kind of anti-moral Western government we currently suffer - or else deliberately recreating the harshness of 50 percent naturally selected child mortality. Appalling prospects.

Nonetheless, mutation accumulation and the consequent changes in human functioning and behaviour should be acknowledged, studied, measured, and taken into account.

Andrew said...

This evoked Tolkien imagery to me. The geniuses leaving permanently (like the Elves) to a better place.

I have a deep ingrained cultural notion that we must find a solution, or that this can't be right, etc. but Christianity tells us the true nature of these events - that time isn't cyclical and the fix is outside this world.

Bruce Charlton said...

@Andrew - If the above scenario is truly wrong, I would be delighted! But, so far, that is what the evidence seems to say.

Franz von Baader said...

"Of course, I am *not* approving of high child mortality rates, the near elimination of which has been perhaps the greatest contribution of modernity to genuine human happiness. "

Dysgenic breeding patterns lead to illnesses, both mentally and physically, that are *decreasing* "happiness" (which is not very important anyway; suffering is central to Christianity). This world is not meant to be a paradise, quite the opposite.

So the above is clearly wrong: not only is happiness of little importance, it is not even true that it increases only because the number of humans increased. If the population is mostly ill, especially mentally, it will be more depressed and suicidal, leading to antinatalist thoughts.

Bruce Charlton said...

@FvB - "the above is clearly wrong" - not so.

It is just not the whole story.

If we must decide one way or the other (because neutrality is not an option) whether mass death of young children is either a Good or a Bad thing - then obviously it is a Bad thing.

At a micro level we would want it Not to happen, and should strive for it not to happen. Anything else woyld be monstrous!

Yet of course there is a context. 'Strive' in a local and specific way (our own children, for example); and 'strive' up to a point (because there are other priorities in life - for example our spouse and already-born children).

But strategic public policy is a different matter.

sykes.1 said...

In Darwinian theory, evolution occurs via differential reproduction. Those somehow best adapted or most fit on average raise more children to maturity. And to the extent the parents fitness and adaptation are genetically related, the children are generally more fit and better adapted.

So, the question is, Is not the Welfare Queen better adapted to modern society than the high IQ professional woman with no children? The answer is, Yes.

The second question is, Can the Welfare Queen and her children sustain the society that nurtured them? The answer is, No.

There will be no Singularity.

Bruce Charlton said...

@sykes - Indeed, and there are *many* other examples of the way in which selection is *strongly* favouring those who are parasitic upon modern society - for example violent male criminals average high fertility; the most intelligent/ highly educated women have extremely low average fertility and so forth. The demographic changes in this direction are very rapid indeed; and would take a long time to reverse Even If (which is not the case) there was any attempt to reverse them. The odds are strong that our society will not long survive.

e.g. https://mouseutopia.blogspot.com/